Friday, March 1, 2013

Citizen Science: Public to join cancer cure hunt

Skin cancer cells The public would be able to help find a cure for cancer, including skin cancer

Giants of the technology world and cancer researchers are teaming up to come up with ways to let the general public hunt for cures for cancer.
It is an attempt to mirror some of the success in unleashing the public in the hunt for objects in space.
Cancer Research UK, along with Amazon, Facebook and Google, is trying to get people to search for mutations in DNA which lead to cancer.
The data needs to be analysed by eye, but there are not enough scientists.
There has been rapid progress in working out the exact sequence of a tumour's DNA.
Combining this information from multiple tumours allows researchers to hunt for the critical mutations which turn a normal healthy part of the body into a deadly cancer.
But the amount of data involved is massive and computers cannot find the subtle differences which may give clues to the genetic causes of cancers, which in turn can lead to treatments.
Graph Researchers looks at graphs like this to point which mutations are common in cancers
Prof Carlos Caldas, from the University of Cambridge, said: "Future cancer patients will receive treatment targeted to the genetic fingerprint of their tumour and we hope this exciting project will bring forward the day this becomes a reality.
"We're making great progress in understanding the genetic reasons cancer develops.
"But the clues to why some drugs will work and some won't, are held in data which need to be analysed by the human eye - and this could take years.
"By harnessing the collective power of citizen scientists we'll accelerate the discovery of new ways to diagnose and treat cancer much more precisely."
Researchers, computer programmers and games designers will meet this weekend to find a ways of converting the dense raw data into something more "game-like".
The chief executive of Cancer Research UK, Dr Harpal Kumar, said: "We're bringing together the cream of the UK's technology specialists with our scientists as a collective force to accelerate cures for cancer outside the laboratory.
"This exciting event will provide a channel to help our scientists discover new genetic drivers of cancer that would otherwise take years to identify."
They aim to have the project up and running by the summer.

Newcastle manager Pardew disappointed with Ben Arfa's fitness

Mar 1, 2013 
The 25-year-old has been out since December with a hamstring injury and has suffered setbacks during his recovery, and his boss is unhappy with his physical condition
Newcastle boss Alan Pardew says he is disappointed with Hatem Ben Arfa's level of fitness as he continues his recovery from injury.

The France international has been out with a hamstring injury since December, and has suffered numerous setbacks. In his absence, new signing's Yoan Gouffran and Moussa Sissoko have impressed, whilst Jonas Gutierrez has proved an able understudy.

The Magpies boss says that there may be a cameo appearance for Ben Arfa at Swansea, and insists there is no blame attached to the injury; he merely wants to explain to the Newcastle fans why the attacker is not playing.

He told reporters: "I have to say his condition has disappointed me this week, and we will be working hard in the next few days to get him up to speed because he lacks a bit of fitness, for sure.

"I just think it's something we need to push him on at. His upper body strength is there, but we want to work on his general fitness. I think that needs to improve.

"My gut feeling is that I'll take him to Swansea but he will work when he's with me and he'll work hard. Really and truly if I do decide to use him, it will be a 10 minute cameo.

"I think it was pretty close to deciding to attack it again with an operation, that's how bad it was. We took the option not to do that, probably in the long term that was the best decision because you do not want to have surgery at any time really.

"I remember seeing a picture of it and it was a complete bleed in the whole leg so he had a lot of fluids and bad stuff in there.

"There is no blame attached to him. I am not being critical of him. I am just telling our fans because I know our fans are like: 'let's get Hatem in the team,' and he ain't ready."

Benitez as expendable as Mourinho while Abramovich seeks a different kind of stability

March1, 2013 
By Richard Offei-Addo Afeinyie,The News
Credit:goal.com
The Chelsea owner's model for success is to weaken the power of the manager while surrounding him with backroom staff who provide a smooth transition from one regime to the next
Bet: Returns: Chelsea £14.00 Draw £43.30 West Brom £85.00 Coral
SPECIAL REPORT

As Rafael Benitez laid the foundations for further activity at Chelsea's managerial revolving door, scrutiny falls again on the club's coaching model.

The Spaniard all but sealed what is likely to be his ugly fate with a calculated criticism of the team's supporters and the man who deemed him a suitable replacement for Roberto Di Matteo following Wednesday's win over Middlesbrough.

During Roman Abramovich's decade-long reign, however, the first-team manager has always been expendable. Benitez's astonishing post-match tirade will have done nothing to persuade his employer that he is anything but.

Abramovich's stance is nothing new and is not regarded by the Russian owner or, indeed, the board who carry out his instructions, as unhealthy or counter-productive.

By contrast, Chelsea officials believe that the club's coaching set-up is stable and logical. To outsiders who only focus on the role of the manager, it does not look that way but insiders at the Cobham training base feel that the building blocks are in place for a smooth transition from one regime to another.

THE COMPANY MEN
TECHNICAL DIRECTOR
Michael Emenalo
ASSISTANT FIRST-TEAM COACH
Steve Holland
ASSISTANT FIRST-TEAM COACH
Bolo Zenden
ACADEMY MANAGER
Neil Bath
UNDER-21s MANAGER
Dermot Drummy
DIRECTOR OF FOOTBALL OPERATIONS
Mike Forde
SENIOR OPPOSITION SCOUT
Mike McGiven
GOALKEEPER COACH
Christophe Lollichon
As one source explained to Goal.com: "The first-team manager is expendable at Chelsea but that has always been the case under Abramovich.

"This model is replicated around Europe and is likely to become more common in England in the future.

"Owners like Abramovich don't want the manager to be the main man at the club. They don't like the fact that he can have so much power over the football operation, for instance in the agents' fees spent on the players he wants.

"They want the manager to work alongside the sporting director or director of football, who they feel is their man. They know the head coach role is only dependent upon results and they don't see why that man should have too much power.

"The stability at Chelsea lies not in the dugout, like it does at Manchester United or Arsenal, but in the permanence of key members of the backroom staff."

Take assistant first-team coach Steve Holland, who joined Chelsea from Stoke City in August 2009 to manage the reserves before taking on a first-team coaching role two years later under Andre Villas-Boas.

Holland is known within the game as a highly regarded coach and has established himself as an important conduit beween the first team and the academy, as well as the first-team and technical director Michael Emenalo, who is regarded as Abramovich's eyes and ears at Cobham.

As someone who shares the No.2 duties with Bolo Zenden, Holland is part of Benitez's inner circle but partly removed from it, too. He knows that Abramovich does not like the coaches to get too close to the manager.

"Everyone is aware of what happened to Paul Clement," the source added of the former first-team coach who had been fast-tracked through the coaching set-up during his second spell at the club. "He got too close to Carlo Ancelotti and paid with his job when Carlo was dismissed."

Holland will most likely be working under his fourth manager in two years before too long but is a baby of the behind-the-scenes machinations compared to other influential members of the backroom staff.

Neil Bath joined Chelsea in 1993 and has managed the Academy since 2004. Under-21s manager Dermot Drummy joined the club from Arsenal in 2006. Director of football operations Mike Forde has been at Chelsea since 2007 and now sits on the board.

Other familiar faces at Cobham include senior opposition scout Mick McGiven, whose first Chelsea job was in 1990, and goalkeeper coach Christophe Lollichon, a close ally of Petr Cech first at Rennes and, then, in west London since 2007.




"The point is that there is stability in Chelsea's coaching set-up," the source explained. "Yes, the manager comes and goes and, yes, that does have ramifications for player power but Abramovich feels it is a model that works. For him, the proof is in the trophy cabinet."

In England, there is a culture of the manager running the show, or at least being seen to run it through the medium of staged press conferences and match day touchline posturing.

The cult of the manager is all pervasive. As long as Ferguson and those who seek to imitate him, like David Moyes and Sam Allardyce, are around, the traditional view that the manager is god will be reinforced.

By tearing up such a well-thumbed script, the Chelsea model simultaneously weakens the powerbase of the manager, something which Benitez has found hard to accept, while strengthening the hand of the owner.

Yet Abramovich has a Champions League, three Premier League titles, four FA Cups and two League Cups to show for doing things his way.

He is painted as an impatient, ruthless owner who is as demanding as he is unforgiving of the man who picks the team.

But this Russian, by Premier League standards, is also a revolutionary.
Sports Update...
By Richard Offei-Addo Afeinyie.March 1,2013.
Liverpool manager Brendan Rodgers expects Luis Suarez, 26, to still be at Anfield next season even if they fail to qualify for Europe, after receiving
assurances from the forward's agent that his client is happy at the club.

Source: The Times
Rafael Benitez will be in charge of Chelsea's game against West Bromwich Albion
on Saturday, but the Blues are considering replacing him with Avram Grant until the end of the season before bringing Jose Mourinho back as
manager in the summer.

Source: London Evening Standard

Rafa Benitez has said he's had enough of the Chelsea fans. ''I have already proven that i want to win as much titles for the club as i can, the fans are only wasting their time'' - Rafa Benitez.

''The fans should show us some more support instead of the hate they give us, especially towards me, it is only bad for the club.'' - Rafa
''The problem is the fans who aren't supporting us at all, that doesn't make the players as happy as before, i want the fans to stop hating and show us some support because its their fault that we are having a bad form right now.'' - Rafa
David Beckham has warned Manchester United that Cristiano Ronaldo will be inspired by his return to Old Trafford for the second-leg of Real Madrid's Champions League tie with the Premier League leaders.
Liverpool manager Brendan Rodgers expects Luis Suarez to still be at Anfield next season even if they fail to qualify for Europe, after receiving assurances from the forward's agent that his client is happy at the club.
Benitez : "Im here until May"

Chelsea interim boss Rafael Benitez says he has an "excellent" relationship with owner Roman Abramovich and will remain at the club until the summer.
 
 
 
What Sort Of Ingrate Behaviour Is This? Pianim And Wereko-Brobbey Have Slighted Kufuor Immensely
 
March 1,2013       
 


 
 

 
 

 

 

 
Former Member of Parliament of the New Patriotic Party for Ahafo Ano South constituency, Stephen Kwaku Balado Manu, says the recent comments by economist and investment consultant, Mr. Kwame Pianim, might be borne out of his “poverty-stricken” life.

Hon. Balado Manu stated strongly that Mr. Pianim might have made such comments because he needs financial assistance from his sympathizers.

Reacting to the disparaging remarks by the one-time NPP staunch member on Peace FM’s “Kokrokoo” Thursday morning, Hon. Balado Manu told host Kwami Sefa Kayi that he (Mr. Pianim) came hard on the leadership of the party “because he wants to receive payment for his job done, maybe he’s not been paid, so he will be remunerated. It would have been better for him if we had understood it this way.”

Mr. Pianim, an outspoken politician, in an exclusive interview with Africawatch magazine, blamed the NPP national executives for exhibiting “intellectual and mental laziness”, adding that the party is heading in the wrong direction.

Mr. Pianim added that “the boycott [of the President’s inauguration] somehow portrayed the NPP executives as confused people”.

Mr. Pianim had called for “an emergency national congress of the party to decide on its boycott of certain key national events” and other activities involving the President.

According to him, the NPP leadership is “not thinking logically” and so, is going down “a dangerous slope” as a result of the decision to distance themselves from all events headlining the President.

But Hon. Balado, contributing to a panel discussion, surmised that the one-time NPP presidential hopeful does not seek the good of the party but only his parochial interest.

In a submission tinged with innuendos and proverbs, the former NPP MP questioned the rationale behind the remarks asking what his real motives are saying even “If it is the grand design of the National Council” to pave another way for Nana Addo (to still be the party’s flagbearer) “what is his problem? Is Nana Addo not an NPP member?...So, is he making those comments because he doesn’t want Nana Addo to lead again? What offence has Nana Addo committed against him?”

“I will understand him because it is hard to make ends meet. But he should remember that this is an NPP issue, if he has returned after leaving the party…If he has returned (because i'm not too sure if he is still an NPP member), let him not try to muddy the waters,” he stated.

Touching on the remarks made by another NPP stalwart, Dr. Charles Wereko Brobbey, who also shared similar views with Mr. Pianim on the party’s position, Hon. Balado described him as an “ingrate” because according to him, he has benefited immensely from the NPP and as a result, did not expect him to lash out at the leadership in the manner that he did.

Dr. Wereko Brobbey in a statement to the NPP leadership implored the party to direct its energies towards winning the 2016 elections and stop what he referred to as “self promotional gimmicks.”

He was appalled by the party’s decision not to take part in the two bye-elections in Akatsi and Buem, saying the reasons they cited were “illogical and nonsensical.”

"The NPP is boycotting Parliamentary bye-elections because it is in dispute with the EC. Why not extend this illogical and nonsensical act by asking all the Party’s MPs in all of the constituencies affected by the 4700 polling stations cited in the Supreme Court Petition to step aside from Parliament pending the determination of the case. Whilst we are at it, let the NPP in Parliament abandon the farce of taking part in the vetting of Ministers nominated by the President whose election they do not recognise, again until such time as the Supreme Court pronounces in the petition.

“Also, since it is only President Mahama who can commit the public funds of Ghana, let the NPP in Parliament suspend its participation in Parliament since that body’s agenda is only to debate and approve policies and programmes which impose a charge on the Public purse of Ghana," portions of his statement read.

He also held a view that the NPP should completely boycott Parliament since they are challenging the President’s legitimacy in court.
 





Hon Balado Manu
However, the former Ahafo Ano South MP, who raised a number of questions about the logic in the comments, explained that Mr. Wereko Brobbey may just be living up to his nickname “Tarzan” which he interpreted as “Champion”, hence an attempt by him to show off his bravado.

He said the conduct of Dr. Wereko Brobbey proves that he is an ungrateful person, adding that if he genuinely had a bone of contention with the party, he would have channeled his concerns directly to the party’s leadership.

“You, being the wise person; if everybody had gone to a different party or followed your UGM during the time you abandoned your Uncle’s legacy, where would the NPP have been?” he questioned.

He discounted claims that the NPP is gradually becoming an Akyem-based party and rhetorically asked if the tribes of the National Chairman, National Women’s Organiser, the National Youth Organiser and National Organiser indicate there are Akans or Akyems.

To him, their comments are an affront to the National Executive Committee (NEC), the highest decision-making body of the party and ex-President Kufuor, who in his wisdom, lobbied to have both personalities accepted as prodigal members.

In conclusion, the former NPP MP described the two, messrs Kwame Pianim and Dr. Wereko Brobbey, as nothing but “traitors”.
 

As tablets boom, e-readers feel the blast

The Kindle Paperwhite, left, and Nook Simple Touch are leading e-readers, but booming tablet sales could spell doom.
The Kindle Paperwhite, left, and Nook Simple Touch are leading e-readers, but booming tablet sales could spell doom.

(The News)... One thing appeared certain when Barnes & Noble announced Thursday how much money its Nook e-readers brought in over the past three months: The news would be lousy.
And it was. Revenue from the company's Nook division for its fiscal 2013 third quarter declined 26% from the same period a year ago, primarily as a result of slumping sales of the devices.
Is the bookseller just losing ground to rival Amazon and its market-leading line of Kindles? Perhaps. But many tech analysts see something else happening: the booming market for tablet computers is starting to make the dedicated e-reader obsolete.
"It's not that the Nook failed," said James McQuivey, a digital analyst at Forrester Research. "It's that the world of tablets exploded, going faster than anyone expected, putting us in a place where tablets are now a fundamental part of our computing and lifestyle entourage, not just a handy device to consume a bit of media."
Apple rocked the computing world in 2010 with the release of the iPad, introducing the world to the concept of user-friendly tablets. While they already existed in some form, tablets were pretty much unknown to all but the most tech-savvy among us. Since then, all Apple has done is sell more than 120 million of them.
Competitors struggled to come up with a worthy alternative until late the next year, when Amazon -- already a leader in the e-reader market -- rolled out its simpler, smaller Kindle Fire, priced at $199, far lower than the iPad.
Its relative success not only inspired the launch of devices such as the Google Nexus 7, but it likely nudged Apple into the new midsize tablet market with the iPad Mini.
The net effect? Anyone interested in a tablet now probably has a price point with which they'll be comfortable. And tablets, which are priced similarly to top e-readers, also work well for reading e-books. Throw in Internet, apps and e-mail -- all on a full-color tablet screen -- and e-readers suffer by comparison.
This trend has been particularly unkind to the Nook.
During the quarter that included last year's holiday season, Barnes & Noble's Nook business, which includes e-readers and e-books, suffered a 12.6% sales decline over 2011, bringing in just $311 million.
Earlier this month, the company said the Nook-related losses they'll announce Thursday would be even bigger than previously expected. The bad news came despite Barnes & Noble slashing the price of its Nook Simple Touch e-reader in December to $79.
Amazon doesn't release detailed sales figures. But the Kindle clearly emerged as the market leader in the past couple of years, after doing neck-and-neck battle with the Nook early on. In the last quarter of 2012, the company said it increased its sale of e-books and other content for Kindles and similar devices by 22% over the same quarter in 2011.
But analysts expect that even Amazon's success with dedicated e-readers will fade.
"It's a rough market to compete," said Michael Gartenberg, a tech-industry analyst with research firm Gartner Inc. "On one hand, devices like the iPad dominate the consumer tablet experience which includes reading. On the other hand, less demand for dedicated devices had helped Amazon, which already established a strong brand presence with Kindle as part of a much larger personal-cloud ecosystem."
Amazon has transitioned well into that new world. This holiday season, the new Kindle Fire HD was Amazon's top-selling device in the Kindle line, the company announced. Second? The older, and price-reduced, Kindle Fire.
And unlike Barnes & Noble, which is strongly branded as a bookstore, Amazon has created its own online universe of sales, McQuivey said.
"As part of Barnes & Noble, the Nook is stuck as a media device offered to media consumers when in reality the tablet business is poised for much more than this," he said.
Many reviewers actually liked Barnes & Noble's response, the Nook Tablet, better than the first-generation Kindle Fire. But, as McQuivey notes, its lack of an expansive ecosystem hurt it.
When the first wave of tablets hit the market, three years after the first Kindle and a year after the Nook, e-readers could still boast a significantly better reading experience. E-ink felt significantly more like printed text than a sometimes glare-prone tablet screen, which was difficult to read in bright sunlight.
But now, every one of the major tablet makers boasts high-definition screens that ratchet up not just the quality of video and snazzy graphics but the way text appears in reading apps.
The general consensus among observers is that they haven't caught up to the dedicated e-readers in text quality quite yet, but give them time.
"If you love reading and are looking to invest a chunk of money into a device as a dedicated e-reader, then the iPad is not your best bet," Cesar Torres, of CNN content partner ArsTechnica, wrote last year in a review comparing the third-generation iPad to e-readers such as the third-generation Kindle. (That iPad has the same screen as the most recent one).
"The value you can get from devices like the Kindle (or several other competitors like the Sony Reader or Kobo), will allow you to save money to spend on what is presumably your main passion: books."
But for folks wanting a more complete computing experience, he wrote, the difference was already negligible.
"The trouble comes when you start to think of your e-reader as more than an e-reader," he wrote. "E-ink Kindles are abysmal at Web browsing, for example, and they don't run popular apps and games like the iPad and other tablets on the market today.
"There are other types of reading, like webpages and magazines, that matter just as much as books to many readers, too. For those needs, an iPad's retina display will display images and text like a champ."
So, is there any future for dedicated e-readers?
McQuivey says that as Amazon continues to establish itself as an Internet clearinghouse for all sorts of goods (both physical and digital), the Nook, which got a $300 million infusion from Microsoft last year, could look to selling textbooks and other educational tools.
A rumored plan to split the e-book division off from Barnes & Noble's brick-and-mortar stores could come as early as Thursday and would be a perfect jumping-off point, he said.
"All the more reason for Nook to separate from Barnes & Noble, turning to its investment partners like Microsoft and Pearson and saying, 'Let's see how far we can take this platform into productivity and education,' " he said.
"Of course there's risk there, but there was risk in getting into the tablet business."

'I'm just a pilgrim,' Benedict XVI says in public farewell

By Richard Offei-Addo Afeinyie,The News.
March 1, 2013
The faithful fill St. Peter's Square as Pope Benedict XVI attends his last public audience on Wednesday, February 27, in Vatican City. Benedict's decision to resign earlier this month caught a lot of Vatican watchers, apparently even some in his inner circle, off-guard. The faithful fill St. Peter's Square as Pope Benedict XVI attends his last public audience on Wednesday, February 27, in Vatican City. Benedict's decision to resign earlier this month caught a lot of Vatican watchers, apparently even some in his inner circle, off-guard.

Benedict XVI's final papal audience

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Benedict XVI's time as pope came to a historic end Thursday, as he became the first pontiff in six centuries to resign as leader of the world's Roman Catholics, who now number 1.2 billion.
Torchlit crowds stood before the gates of the Castel Gandolfo residence, waiting to see the Swiss Guards, the soldiers who traditionally protect the pope, salute and close the doors on the stroke of 8 p.m.
The guards' departure from the papal summer home brings Benedict's papacy to a formal end. The protection of Benedict there falls now to Vatican police.
The process of transition to that new pope now begins. Meanwhile, the Catholic Church is without a leader.
Pope: 'The Lord seemed to be sleeping'
Symbolizing that gulf at the top, all Benedict's tweets as @Pontifex have been archived. Instead, the account's Twitter page reads only "Sede Vacante," or empty seat.
Earlier, his final words were given to some 10,000 people who had gathered at Castel Gandolfo to bid him an emotional farewell.
"I am no longer the pope but I am still in the church. I'm just a pilgrim who is starting the last part of his pilgrimage on this earth," he said.
He thanked them for their friendship, on a day "different for me than the preceding ones" -- and indeed almost unprecedented for the Roman Catholic Church.
"I would still -- with my heart, with my love, with my prayers, with my reflection, and with all my inner strength -- like to work for the common good and the good of the church and of humanity," he said.
"I feel very supported by your kindness. Let us go forward with the Lord for the good of the church and the world. Thank you."
Smiling slightly, he made the sign of the cross to bless the crowds and disappeared into the building.
It is likely to be the last time he is seen in public.
Benedict, who will now be known as "pontiff emeritus," will spend the next few weeks at the peaceful, hilltop Castel Gandolfo residence before moving to a small monastery within the Vatican grounds.
The first pope to resign in 598 years, his departure ushers in a period of great uncertainty for the church as the cardinals work to elect the next pontiff.
Pomp and ceremony
Benedict earlier left Vatican City for the last time as pope amid pomp and ceremony.
An honor guard of Swiss Guards lined up to bid him farewell as, looking frail and carrying a cane, he left the papal apartment to applause from senior Vatican officials and staff.
The sound of bells from St. Peter's Basilica chimed across the city of Rome as the helicopter carrying him to Castel Gandolfo looped overhead, passing above landmarks like the Colosseum.
Although Benedict will eventually return to Vatican City to live out his days, he will never again set foot there as pope.
Seals will be placed on the entrance to the pope's Vatican apartment, the Vatican said -- to be removed only when the next pontiff enters.
His symbolic Fisherman's Ring and papal seal will be "destroyed" by means of making scratch marks so that they can no longer be used to seal documents, said Vatican spokesman Federico Lombardi.
Benedict's final tweet, sent at 11 a.m. ET from his @Pontifex account, read: "Thank you for your love and support. May you always experience the joy that comes from putting Christ at the centre of your lives."
The account will remain dormant until the next pope decides whether he wants to use it, the Vatican said.
'Unconditional obedience'
Pope Benedict's last day as pontiff
What's next for Pope Benedict?
Italian press 'more opera than news'
Pope: 'My strength has diminished'
Benedict entered his final day as pontiff with an unusual act -- a pledge of "unconditional obedience" and respect to whoever takes up the reins after his dramatic resignation later.
His promise came in a last meeting Thursday morning with the cardinals who will pick his successor, almost certainly from within their own ranks.
"I will continue to serve you in prayer, in particular in the coming days, so that you may be touched by the Holy Spirit in the election of a new pope," he said.
His words appeared designed to answer concerns that the presence of a former pontiff might lead to confusion or competing loyalties once the new pope is installed.
Benedict told the cardinals it was a "joy to walk with you" during his nearly eight tumultuous years at the head of all Catholics worldwide.
Pope says farewell to Twitter account
Another Vatican spokesman, the Rev. Thomas Roscia, said he believed 144 cardinals had attended Benedict XVI's farewell to them as pope. That includes both cardinal-electors, who are under the age of 80, and cardinals who are not eligible to vote for the next pope.
Not all the 115 cardinals eligible to vote were present, Lombardi said.
Two cardinals are suffering ill health, making their attendance uncertain, although arrangements may be made to enable them to vote, Roscia said.
The Vatican has said it wants to have the next pontiff in place in time for the week of services leading up to Easter Sunday on March 31.
A series of meetings to set the timetable for the conclave -- the closed-door assembly to elect a new pope -- will begin early next week, said Lombardi. The cardinals will receive the formal invitation to attend on Friday.
The meetings, known as general congregations, bring together all the cardinals, electors and non-electors, before the conclave begins. They are intended to be an opportunity to reflect on the current state of the church.
Secret election
In their meeting Thursday morning, the cardinals gave Benedict a standing ovation, and then one by one each met Benedict to say a final few words.
Cardinal Daniel DiNardo of Texas said at a news conference held with fellow U.S. cardinals that it had been "a very moving moment with Pope Benedict."
"There was a note of sadness in saying farewell to this man who has been our spiritual father for the last eight years," said Cardinal Sean O'Malley of Boston.
"At the same time it was very edifying to see how much people love him and respect him."
Cardinal Roger Mahony, the retired archbishop of Los Angeles, tweeted after meeting Benedict that he had asked Benedict to pray for the people of Los Angeles. "He grasped my hand and said 'Yes'!!" Mahony said.
The current Catholic archbishop in Los Angeles earlier this month disciplined Mahony for his mishandling of "painful and brutal" allegations of sexual abuse by priests. Mahony's decision to travel to Rome to take part in the election of the new pope has been controversial because of that.
DiNardo and O'Malley said they would pray for guidance in choosing the new pope.
"I consider it one of the most important activities that I will be engaged in as a priest and a cardinal," said O'Malley, for whom the conclave will be his first.
"I think the discussions that we will have in the congregations will be the most important intellectual preparation that we have -- certainly the spiritual preparation has already begun.
"Our people back home and throughout the world are all praying that we will be guided to be able to choose the very best person to lead us."
Twitter shutdown
Cardinals are forbidden to communicate with the outside world -- now including by Twitter -- during the conclave, held within the Sistine Chapel. There is no Internet access inside Santa Marta, where the cardinals will stay during the conclave, Lombardi said.
Cardinal Gianfranco Ravasi of Italy, tipped as a possible future pope, tweeted Thursday morning that he would be away for a few days.
A number of other cardinals, including Ghanaian Peter Turkson, also considered a frontrunner, and New York's Timothy Dolan are also present on Twitter.
Benedict, who will not be involved in the election, will not get any advance notice of who his successor will be, Roscia said. The pope emeritus will find out who has been elected at the same time as the rest of the world.
Cardinal Javier Lozano Barragan of Mexico, who turned 80 last month and so is not a cardinal-elector, would not be drawn to comment Wednesday on who the next pope might be.
As to whether the cardinals are talking to each other about it now, he told CNN: "There are contacts, of course there are contacts. But what people talk about, who knows?
"There is a saying in Rome: He who enters the conclave as a possible pope comes out a cardinal."
Mired in scandal
Benedict's resignation opens up the prospect of unforeseen opportunities and challenges for the Roman Catholic Church.
Many are wondering whether a new pontiff will choose to lead the church in a different direction -- and can lift it out of the mire of scandal that has bogged down this pope's time in office.
Even as Benedict's final week began, Vatican officials were trying to swat down unsavory claims by Italian publications of an episode involving gay priests, male prostitutes and blackmail. Then the news broke that Benedict had moved up the resignation of a Scottish archbishop linked over the weekend by a British newspaper to inappropriate relationships with priests.
Last year, leaks of secret documents from the pope's private apartment -- which revealed claims of corruption within the Vatican -- prompted a high-profile trial of his butler and a behind-doors investigation by three cardinals.
Their report, its contents known so far only to Benedict, will be handed to his successor to deal with, the Vatican said.
Vatican magistrates may have authorized the tapping of two or three telephone lines during the cardinals' inquiry into the leaks, Lombardi acknowledged Thursday, responding to a report in the Italian weekly magazine Panorama that claimed a large-scale surveillance operation had been run.
Lombardi denied there had been "a massive" operation on the scale reported by the magazine, saying there is "no foundation" for the article. Roscia said that if there was any wiretapping or surveillance, "it's a very small process."
Both spokesmen denied that the operation had been ordered by the three cardinals, saying that if it had happened, it was ordered by magistrates.
At the same time, the church faces continued anger about what many see as its failure to deal with child sex abuse by priests.
So, when Benedict announced on February 11 that he would step down, there was inevitable speculation that his move was in some way linked to the brewing scandals.
Dolan, the most senior Catholic cleric in the United States, told CNN's Christiane Amanpour that there was an urgent need for a recovery and renewal in the church
The new pope won't seek to alter the teachings of the church, but could change the way they are presented, Dolan said.
'The Lord seemed to sleep'
The danger for the Vatican is that the scandals risk overshadowing what others see as Benedict's real legacy to the church: his teaching and writings, including three papal encyclicals.
Proof of the Vatican's irritation came with a stinging statement Saturday complaining of "unverified, unverifiable or completely false news stories," even suggesting the media is trying to influence the election of the next pope.
The constant buffeting by scandal will doubtless also have taken a toll on an 85-year-old man whose interests lie in scholarly study and prayer rather than damage control.
Benedict suggested as much at his final general audience Wednesday, when in front of cheering crowds in St. Peter's Square he spoke of steering the church through sometimes choppy waters.
There had been "many days of sunshine," he said, but also "times when the water was rough ... and the Lord seemed to sleep."
Benedict also called for a renewal of faith, and for the prayers of Catholics around the world both for him and his successor.
Italian iReporter Giovanni Francia was in St. Peter's Square to witness the scene. "There was a good atmosphere, (but) full of the sense we have lost a sort of 'grandfather,'" he said. "Now we are a little more alone."