Half the Syrian population has been displaced by the fighting |
UN Secretary General Ban Ki-moon has called for "flexibility" at talks in Vienna between the countries backing rival sides in the Syrian civil war.
He urged the five main participants - the US, Russia, Iran, Saudi Arabia and Turkey - to abandon "national perspectives" for "global leadership".
These are the first such talks to include Iran, which - with Russia - backs Syrian President Bashar al-Assad.
The US and its allies insist Mr Assad cannot be part of any solution.
The four-year-old war in Syria, which began with an uprising against Mr Assad, has left 250,000 people dead and forced half the country's population - or 11 million people - from their homes.
Russia and Iran have recently stepped up their military involvement in the conflict, backing forces loyal to Mr Assad.
The US, Turkey, Saudi Arabia and other Gulf Arab nations have long insisted Mr Assad cannot play any long-term role in Syria's future.
On the eve of the talks, Mr Ban urged the five main participants to think beyond their immediate interests.
"The longer they take their own national perspectives, the more people will suffer, and the whole world will suffer," he said. "As I always say, there is no military solution."
Saudi Arabia's Foreign Minister Adel al-Jubeir earlier told the BBC that Iran must accept the removal of Mr Assad as part of any solution to the conflict.
Mr Jubeir told the BBC that there was "no doubt" Mr Assad could not remain in office.
"He will go either through a political process or he will be removed by force," he said.
Meanwhile, Iranian Foreign Minister Mohammad Javad Zarif said that other powers had realised that there was no way reaching "a reasonable solution" to the Syrian conflict without involving Tehran.
Foreign ministers held informal talks in Vienna on Thursday, with the substantive discussions scheduled for Friday.
Speaking after meeting Mr Zarif, the EU's foreign policy chief Federica Mogherini said the Vienna talks would bring together "all the relevant actors playing around the same table, trying to define a common space for the beginning of a political process".
US Secretary of State John Kerry also met Mr Zarif on Thursday, as well as the Russian Foreign Minister, Sergei Lavrov, and the foreign ministers of Saudi Arabia and Turkey.
Foreign ministers from the UK, France, Germany, Egypt, Lebanon and the EU have also confirmed they will attend the meeting, and other Middle Eastern powers are also expected.
A Western diplomat called the Vienna talks "embryonic", while another said that simply keeping opposing sides from walking out would count as success.
Millions have been forced from their homes because of the conflict |
Analysis: BBC diplomatic correspondent Bridget Kendall
Many Western diplomats have played down expectations about this gathering, given how complex and bitter the conflict there has become.
One official said it wasn't even a first step towards a peace process, just a tentative bid to seek common ground, with no one really sure if that is possible.
Already the United States and its European and Arab allies, plus Turkey, have given some ground on the critical question of President Assad's role in any future process of transition, suggesting that although he would have to step down, it didn't have to be immediately.
The key question now is whether his two main backers, Russia and Iran, will give any ground on their side.
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